Publications Theme: HIV

HIV

High mortality in subjects with both diabetes and HIV in sub-Saharan Africa


Burgess PI, Harding SP, Kayange PC, van Oosterhout JJ, Garcia-Finana M, Msukwa G,  Allain TJ. AIDS 2018, 32:2083–2085. Read more

Early experiences integrating hypertension and diabetes screening and treatment in a human immunodeficiency virus clinic in Malawi


Pfaff C, Singano V,  Akello H. Amberbir A, Berman J, Kwekwesa A, Banda V, Speight C, Allain T,  van Oosterhout JJ. Int Health Doi: 10.1093/inthealth /ihy049. Read more

A targeted approach for routine viral load monitoring in Malawian adults on antiretroviral therapy


Mungwira R.G, Divala T.H, Nyirenda O.M, Kanjala M, Choko A, Taylor T.E, Mallewa J, Muwalo F, van Oosterhout J.J, Laufer M.K, Laurens M.B. Tropical Medicine and International Health, 2018; 23 (5): 526-532. Doi: 10.1111/tmi.13047. Read more

Patterns of caesarean section in HIV infected and non-infected women in Malawi: is caesarean section used for PMTCT?


Tenthani L, van Oosterhout JJ, Haas AD, Msukwa M, Phiri N, Chimbwandira F, Tal K, Aebi-Popp K, Estill J, Keiser O. BMC Pregnancy Childbirth. 2018 Apr 12;18(1):95. doi: 10.1186/s12884-018-1722-4. Read more

Prevention of mother-to-child transmission of HIV: a cross sectional study in Malawi


van Lettow M, Landes M, van Oosterhout JJ, Schouten E, Phiri H, Nkhoma E, Kalua T, Gupta S, Wadonda N, Jahn A, Tippett-Barr B. Bull World Health Organ. 2018 Apr 1;96(4):256-265. doi: 10.2471/BLT.17.203265. Read more

She knows that she will not come back: tracing patients and new thresholds of collective surveillance in PMTCT Option B+


Cataldo F, Seeley J, Nkhata MJ, Mupambireyi Z, Tumwesige E, Gibb DM; Lablite team. BMC Health Serv Res. 2018 Feb 1;18(1):76. doi: 10.1186/s12913-017-2826-7. Read more

Patient-level benefits associated with decentralization of antiretroviral therapy services to primary health facilities in Malawi and Uganda


Abongomera G, Chiwaula L, Revill P, Mabugu T, Tumwesige E, Nkhata M, Cataldo F, van Oosterhout J, Colebunders R, Chan AK, Kityo C, Gilks C, Hakim J, Seeley J, Gibb DM, Ford D. International Health. 2018; Jan 10. Doi: 10.1093/inthealth/ihx061. Read more

Dyslipidemia among rural and urban HIV patients in south-east Malawi


Amberbir A, Singano V, Matengeni A, Kawalazira G, Chan A.K, Sodhi S.D, Ismail Z, van Oosterhout J.J. PLoS ONE, 2018. 13(5): e0197728. Doi.10.1371/journal.pone.0197728. Read more

Lopinavir plus nucleoside reverse-transcriptase inhibitors, lopinavir plus raltegravir, or lopinavir monotherapy for second-line treatment of HIV (EARNEST): 144-week follow-up results from a randomised controlled trial


Hakim JG, Thompson J, Kityo C, Hoppe A, Kambugu A, van Oosterhout JJ, Lugemwa A, Siika A, Mwebaze R, Mweemba A, Abongomera G, Thomason MJ, Easterbrook P, Mugyenyi P, Walker AS, Paton NI; Europe Africa Research Network for Evaluation of Second-line Therapy (EARNEST) Trial Team. Lancet Infectious Disease. 2018 Jan;18(1):47-57. doi: 10.1016/S1473-3099(17)30630-8. Epub 2017 Nov 3. PubMed PMID: 29108797; PubMed Central PMCID: PMC5739875. Read more

The treatment of a pregnant HIV positive patient with cryptococcal meningitis in Malawi: case report and review of treatment options


Bright P, Lupiya D, van Oosterhout JJ, Chen YA, Harrison T, Chan AK. Medical Mycology Case Reports 2018; 19:9-12. doi: 10.1016/j.mmcr.2017.10.002. Read more

Models of integration of HIV and non-communicable disease care in sub-Saharan Africa


Njuguna B, Vorkoper S, Patel P, Reid MJA, Vedanthan R, Pfaff C, Park PH, Fischer L, Laktabai J, Pastakia SD. AIDS. 2018 Jul 1;32 Suppl 1:S33-S42. Doi:1097/QAD.00000000001887.PMID:29952788. Read more

Opportunities and challenges for evidence-informed HIV-noncommunicable disease integrated care policies and programs: lessons from Malawi, South Africa, Swaziland and Kenya


Matanje Mwagomba BL, Ameh S, Bongomin P, Juma PA, MacKenzie RK, Kyobutungi C, Lukhele N, mwangi KJM, Amberbir A, Klipstein-Grobusch K, Gomez-Olive FX, Berman, Joshua. AIDS. 2018 Jul 1;32 Suppl:S21-S32.doi:10.1097/QAD.0000000000001885.PMID:29952787. Read more

The treatment of a pregnant HIV positive patient with cryptococcal meningitis in Malawi. Case report and review of treatment options.


Bright Philip D, Lupiya Duncan, van Oosterhout JJ, Chen Amy, S Harrison Thomas, ChanAdrienne K. Medical Mycology Case Reports. 2017 Oct 28;19(2018):9-12. doi: 10.1016/j.mmcr.2017.10.002. Read more

HIV transmission and retention in care among HIV-exposed children enrolled in Malawi’s prevention of mother-to-child transmission programme


Haas AD, van Oosterhout JJ, Tenthani L, Jahn A, Zwahlen M, Msukwa MT, Davies MA, Tal K, Phiri N, Spoerri A, Chimbwandira F, Egger M, Keiser O. 2017 Sep 4;20(1):1-10. doi: 10.7448/IAS.20.1.21947. PubMed PMID: 28884524. Read more

Differences in survival among adults with HIV-associated Kaposi’s sarcoma during routine HIV treatment initiation in Zomba district, Malawi: a retrospective cohort analysis


Singogo E, Keegan T.J, Diggle P.J, van Lettow M, Matengeni A, van Oosterhout J.J, Sodhi S, Joshua M, Taylor B.M. International Health. 2017 Sep 1;9(5):281-7. DOI:10.1093/inthealth/ihx027. Read more

Nucleoside reverse-transcriptase inhibitor cross-resistance and outcomes from second-line antiretroviral therapy in the public health approach: an observational analysis within the randomised, open-label, EARNEST trial


Paton NI, Kityo C, Thompson J, Nankya I, Bagenda L, Hoppe A, Hakim J, Kambugu A, van Oosterhout JJ, Kiconco M, Bertagnolio S, Easterbrook PJ, Mugyenyi P, Walker AS; Europe Africa Research Network for Evaluation of Second-line Therapy (EARNEST) Trial Team. Lancet HIV. 2017 Aug;4(8):e341-e348. doi: 10.1016/S23523018(17)30065-6. Epub 2017 May 8. PubMed PMID: 28495562; PubMed Central PMCID: PMC5555436. Read more

Virological outcomes of antiretroviral therapy in Zomba central prison, Malawi; a cross-sectional study


Mpawa H, Kwekwesa A, Amberbir A, Garone D, Divala OH, Kawalazira G, van Schoor V, Ndindi H, van Oosterhout JJ. J Int AIDS Soc. 2017 Jul 31;20(1):1-5. doi: 10.7448/IAS.20.1.21623. Review. PubMed PMID: 28782332; PubMed Central PMCID: PMC5577730. Read more

Viral Suppression and HIV Drug Resistance at 6 Months Among Women in Malawi’s Option B+ Program: Results From the PURE Malawi Study


Hosseinipour M, Nelson JAE, Trapence C, Rutstein SE, Kasende F, Kayoyo V, Kaunda-Khangamwa B, Compliment K, Stanley C, Cataldo F, van Lettow M, Rosenberg NE, Tweya H, Gugsa S, Sampathkumar V, Schouten E, Eliya M, Chimbwandira F, Chiwaula L, Kapito-Tembo A, Phiri S; PURE Malawi Consortium. J Acquir Immune Defic Syndr. 2017 Jun 1;75 Suppl 2:S149-S155. doi: 10.1097/QAI.0000000000001368. PubMed PMID: 28498184; PubMed Central PMCID: PMC5431274. Read more

HIV Drug Resistance Mutations in Non-B Subtypes After Prolonged Virological Failure on NNRTI-Based First-Line Regimens in Sub-Saharan Africa


Kityo C, Thompson J, Nankya I, Hoppe A, Ndashimye E, Warambwa C, Mambule I, van Oosterhout JJ, Wools-Kaloustian K, Bertagnolio S, Easterbrook PJ, Mugyenyi P, Walker AS, Paton NI; Europe Africa Research Network for Evaluation of Second-line Therapy (EARNEST) Trial Team. J Acquir Immune Defic Syndr. 2017 Jun 1;75(2):e45-e54. doi: 10.1097/QAI.0000000000001285. PubMed PMID: 28129253; PubMed Central PMCID: PMC5427983. Read more

Viral Suppression and HIV Drug Resistance at 6 Months Among Women in Malawi’s Option B+ Program: Results From the PURE Malawi Study


Hosseinipour M, Nelson J.A.E, Trapence C, Rutstein S.E, Kasende F, Kayoyo V, Kaunda-Khangamwa B, Stanley C, Cataldo F, van Lettow M, Rosenberg N.E, Tweya H, Gugsa S, Sampathkumar V, chouten E, Eliya M, Chimbwandira F, Chiwaula L, Kapito-Tembo A, MBBS, Phiri S, PhD and the PURE Malawi Consortium. JAIDS Journal of Acquired Immune Deficiency Syndromes: 1 June 2017 – Volume 75 – Issue – p S149–S155 doi: 10.1097/QAI.0000000000001368. Read more

Frequent malaria illness episodes in two Malawian patients on antiretroviral therapy soon after stopping cotrimoxazole preventive therapy


Nyangulu W.J.S, Mwinjiwa, E,  Divala, T.H, Randy G. Mungwira, Nyirenda O, Kanjala M, Mbambo G, Mallewa J, Taylor T.E, Laurens M.B, Laufer M.K, van Oosterhout J.J. Malawi Medical Journal. 2017 May 4. Read more

Genome-wide association study of nevirapine hypersensitivity in a sub-Saharan African HIV-infected population


Carr DF, Bourgeois S, Chaponda M, Takeshita LY, Morris AP, Castro EM, Alfirevic A, Jones AR, Rigden DJ, Haldenby S, Khoo S, Lalloo DG, Heyderman RS, Dandara C, Kampira E, van Oosterhout JJ, Ssali F, Munderi P, Novelli G, Borgiani P, Nelson MR, Holden A, Deloukas P, Pirmohamed M. J Antimicrob Chemother. 2017 Apr 1;72(4):1152-1162. doi: 10.1093/jac/dkw545. PubMed PMID: 28062682; PubMed Central PMCID: PMC5400091. Read more

Neurocognitive Function at the First-Line Failure and on the Second-Line Antiretroviral Therapy in Africa: Analyses From the EARNEST Trial


Kambugu A, Thompson J, Hakim J, Tumukunde D, van Oosterhout JJ,  Mwebaze R, Hoppe A, Abach J, Kwobah C, Arenas-Pinto A, Walker SA, Paton NI. Journal of Acquired Immune Deficiency Syndromes. 2016;71:506-513 DOI: 10.1097/QAI.0000000000000898 Read more

TSCQ study: a randomized, controlled, open-label trial of daily trimethoprim sulfamethoxazole or weekly chloroquine among adults on antiretroviral therapy in Malawi: study protocol for a randomized controlled trial


Laurens MB, Mungwira RG, Nyirenda OM, Divala TH, Kanjala M, Muwalo F, Mkandawire FA, Tsirizani L, Nyangulu W, Mwinjiwa E, Taylor TE, Mallewa J, Blackwelder WC, Plowe CV, Laufer MK,  van Oosterhout JJ. DOI 10.1186/s13063-016-1392-3 Read more

Breast enlargement in Malawian males on the standard first line antiretroviral therapy regimen: Case reports and review of the literature.


Kwekwesa A , Kandionamaso C, Winata N, Mwinjiwa E, Joshua M, Garone D, Bedell R,van Oosterhout JJ. Malawi Medical Journal. 2015 Sept;27(3): 115-117. DOI: 10.4314/mmj.v27i3.11 Read more

Population level usage of health services, and HIV testing and care, prior to decentralization of antiretroviral therapy in Agago District in rural Northern Uganda


G. Abongomera, S. Kiwuwa-Muyingo, P. Revill, L. Chiwaula, T. Mabugu, A. Phillips, E. Katabira, V. Musiime, C. Gilks, A. Chan, J. Hakim, R. Colebunders ,C. Kityo, D. M. Gibb, J. Seeley, D. Ford13 and for the Lablite Project Team. BMC Health Services Research. 2015;15:527. DOI: 10.1186/s12913-015-1194-4. Read more

CryptoDex: A randomised, double-blind, placebo-controlled phase III trial of adjunctive dexamethasone in HIV-infected adults with cryptococcal meningitis: study protocol for a randomised control trial.


Day J, Imran D, Ganiem AR, Tjahjani N, Wahyuningsih R, Adawiyah R, Dance D, Mayxay M, Newton P, Phetsouvanh R, Rattanavong S, Chan AK, Heyderman R, van Oosterhout JJ, Chierakul W, Day N, Kamali A, Kibengo F, Ruzagira E, Gray A, Lalloo DG, Beardsley J, Binh TQ, Chau TT, Chau NV, Cuc NT, Farrar J, Hien TT, Van Kinh N, Merson L, Phuong L, Tho LT, Thuy PT, Thwaites G, Wertheim H, Wolbers M. Trials. 2014 Nov;15:441. DOI: 10.1186/1745-6215-15-441. Read more

CYP2B6 c.983T>C polymorphism is associated with nevirapine hypersensitivity in Malawian and Ugandan HIV populations.


Carr DF, Chaponda M, Cornejo Castro EM, Jorgensen AL, Khoo S, Van Oosterhout JJ, Dandara C, Kampira E, Ssali F, Munderi P, Lalloo DG, Heyderman RS, Pirmohamed M. J Antimicrob Chemother. 2014 Nov;69(12):3329-34. DOI: 10.1093/jac/dku315. Read more

Hepatitis B virus (HBV) sub-genotype A1 infection is characterized by high replication levels and rapid emergence of drug resistance in HIV-positive adults receiving first-line antiretroviral therapy (ART) in Malawi.


Aoudjane S, Chaponda M, González Del Castillo AA, O’Connor J, Noguera M, Beloukas A, Hopkins M, Khoo S, van Oosterhout J, Geretti AM. Clin Infect Dis. 2014 Nov;59(11):1618-26. DOI: 10.1093/cid/ciu630. Read more

Effect of optional home initiation of HIV care following HIV self-testing on antiretroviral therapy initiation among adults in Malawi: a randomized clinical trial.


MacPherson P, Lalloo DG, Webb EL, Maheswaran H, Choko AT, Makombe SD, Butterworth AE, van Oosterhout JJ, Desmond N, Thindwa D, Squire SB, Hayes RJ, Corbett EL. JAMA. Aug 1, 2014;312(4):372-9. DOI: 10.1001/jama.2014.6493. Read more

The Lablite project: A cross-sectional mapping survey of decentralized HIV service provision in Malawi, Uganda and Zimbabwe.


Adrienne K Chan, Deborah Ford, Harriet Namata, Margaret Muzambi, Misheck J Nkhata, George Abongomera, Ivan Mambule, Annabelle South, Paul Revill, Caroline Grundy, Travor Mabugu, Levison Chiwaula, Fabian Cataldo, James Hakim, Janet Seeley, Cissy Kityo, Andrew Reid, Elly Katabira, Sumeet Sodhi, Charles F Gilks and Diana M Gibb. BMC Health Services Research. 2014 Aug 19;14:352. DOI: 10.1186/1472-6963-14-352 Read more

Peripheral Blood Mitochondrial DNA/Nuclear DNA (mtDNA/nDNA) Ratio as a Marker of Mitochondrial Toxicities of Stavudine Containing Antiretroviral Therapy in HIV-Infected Malawian Patients.


Kampira E, Dzobo K, Kumwenda J, van Oosterhout JJ, Parker MI, Dandara C. OMICS. 2014 Jul;18(7):438-45. DOI: 10.1089/omi.2014.0026. Read more

Follow-Up Visit Patterns in an Antiretroviral Therapy (ART) Programme in Zomba, Malawi.


Beth Rachlis, Donald C. Cole, Monique van Lettow, Michael Escobar, Adamson S. Muula, Farah Ahmad, James Orbinski, Adrienne K. Chan. PLoS ONE. 2014 July 17;9(7): e101875. DOI: 10.1371/journal.pone.0101875 Read more

Incomplete Recovery of Pneumococcal CD4 T Cell Immunity after Initiation of Antiretroviral Therapy in HIV-Infected Malawian Adults.


Sepako E, Glennie SJ, Jambo KC, Mzinza D, Iwajomo OH, Banda D, van Oosterhout JJ, A Williams N, Gordon SB, Heyderman RS. PLoS One. 2014 Jun 24; 24;9(6):e100640. Read more

HIV Associated Neurocognitive Disorders (HAND) in Malawian Adults and Effect on Adherence to Combination Anti-Retroviral Therapy: A Cross Sectional Study.


Christine M. Kelly, Joep J. van Oosterhout, Chisomo Ngwalo, Robert C. Stewart, Laura Benjamin, Kevin R. Robertson, Saye Khoo, Theresa J. Allain, Tom Solomon. PLoS ONE. 2014 Jun 10;9(6): e98962. DOI: 10.1371/journal.pone.0098962 Read more

Adolescent HIV disclosure in Zambia: barriers, facilitators and outcomes.


Gitau Mburu, Ian Hodgson, Sam Kalibala, Choolwe Haamujompa, Fabian Cataldo, Elizabeth D Lowenthal, David Ross. Journal of the International AIDS Society. 17 Mar 2014;17:18866. DOI: 10.7448/IAS.17.1.18866 Read more

A Reduction in Adult Blood Stream Infection and Case Fatality at a Large African Hospital following Antiretroviral Therapy Roll-Out.


Nicholas A. Feasey, Angela Houston, Mavuto Mukaka, Dan Komrower, Thandie Mwalukomo, Lyson Tenthani, Andreas Jahn, Mike Moore, Remco P. H. Peters, Melita A. Gordon, Dean B. Everett, Neil French, Joep J. van Oosterhout, Theresa J. Allain, Robert S. Heyderman. PLoS ONE. 2014 March 18;9(3):e92226. DOI: 10.1371/journal.pone.0092226 Read more

Assessment of second-line antiretroviral regimens for HIV Therapy in Africa.


N.I. Paton, C. Kityo, A. Hoppe, A. Reid, A. Kambugu, A. Lugemwa, J.J. van Oosterhout, M. Kiconco, A. Siika, R. Mwebaze, M. Abwola, G. Abongomera, A. Mweemba, H. Alima, D. Atwongyeire, R. Nyirenda, J. Boles, J. Thompson, D. Tumukunde, E. Chidziva, I.Mambule, J.R. Arribas, P.J. Easterbrook, J. Hakim, A.S. Walker, P. Mugyeni, EARNEST Trial Team. New England Journal of Medicine. 2014 Jul 17;371(3):234-47. DOI: 10.1056/NEJMoa1311274 Read more

Population Pharmacokinetic and Pharmacogenetic Analysis of Nevirapine in Hypersensitive and Tolerant HIV-Infected Patients from Malawi.


Dickinson L, Chaponda M, Carr DF, van Oosterhout JJ, Kumwenda J, Lalloo DG, Pirmohamed M, Heyderman RS, Khoo SH. Antimicrob Agents Chemother. 2014. DOI: 10.1128/AAC.02069-13. Read more

Mitochondrial subhaplogroups and differential risk of stavudine-induced lipodystrophy in Malawian HIV/AIDS patients.


Kampira E, Kumwenda J, van Oosterhout JJ, Dandara C. Pharmacogenomics. 2013;14(16):1999-2004. DOI: 10.2217/pgs.13.188 Read more

Women’s attitudes to HIV testing, disclosure and the involvement of male partners in a rural district of Malawi with high HIV prevalence.


Bedell RA, van Lettow M, Landes M. AIDS Care: Psychological and Socio-medical Aspects of AIDS/HIV. 04 Oct 2013;26(4):483-486. DOI: 10.1080/09540121.2013.841830 Read more

Longitudinal lactate levels from routine point-of-care monitoring in adult Malawian antiretroviral therapy patients: associations with stavudine toxicities.


Chagoma N, Mallewa J, Kaunda S, Njalale Y, Kampira E, Mukaka M, Heyderman RS, and Oosterhout JJ van. C Trans R Soc Trop Med Hyg. 2013;107:615–619. DOI: 10.1093/trstmh/trt074 Read more

Severe toxicity and polymerase-c gene abnormalities in Malawian adults on stavudine-based antiretroviral therapy.


van Oosterhout, Joep J.; Gardner, Kristiane; Mallewa, Janea; Kaunda, Symona; Kampira, Elizabethc; Payne, Brendane; Heyderman, Robert S.; Chinnery, Patrick. Pharmacogenetics and Genomics. 2013 Nov;23(11):624-626. DOI: 10.1097/FPC.0b013e3283655053 Read more

Updating a database of patient level ART data covering multiple and remote facilities in Zomba District, Malawi.


Argarwal M, Bourgeois J, Matengeni A, Bezanson K, van Schoor V, van Lettow M. Public Health Action. 2013 June 21:3(2):175-179(5). DOI: 10.5588/pha.12.0096 Read more

Using concept mapping to explore patient defaulting from an antiretroviral therapy program in the Zomba District of Malawi.


Rachlis B, Ahmad F, van Lettow M, Muula AS, Semba M, Cole DC. BMC Health Services Research. 2013;13:210. DOI: 10.1186/1472-6963-13-210 Read more

A taxonomy for community-based care programs focused on HIV/AIDS prevention, treatment, and care in resource-poor settings.


Rachlis B, Sodhi S, Burciul B, Orbinski J, Cheng A, Cole D. Global Health Action, North America. 16 Apr 2013. DOI: 10.3402/gha.v6i0.20548 Read more

Six-month mortality among HIV-infected adults presenting for antiretroviral therapy with unexplained weight loss, chronic fever or chronic diarrhea in Malawi.


van Lettow M , Åkesson A, Martiniuk ALC, Ramsay A, Chan AK, Anderson ST, Harries AD, Corbett E, Heyderman RS, Zachariah R, Bedell RA. PLoS ONE. 2012 Nov 19;7(11)e48856. DOI: 10.1371/journal.pone.0048856 Read more

Anti-retroviral treatment outcomes among older adults in Zomba District, Malawi.


Negin J, van Lettow M, Semba M, Martiniuk A, Chan AC, Cumming R. PLoS ONE. 2011;6(10). Read more

Outcome assessment of decentralization of ART provision in a rural district in Malawi using an integrated primary care model.


Chan AK, Mateyu G, Jahn A, Schouten E, Mlotha W, Kambanji M, and van Lettow M. Trop Med Int Health. 2010;15s1:90-97. Read more

Burden, Characteristics, Management and Outcomes of HIV-infected patients with Kaposi’s sarcoma in Zomba, Malawi.


Mwinjiwa E, Isaakidis P, Van Den Bergh R, Harries AD, Bezanson K, Thompson C, Joshua M, Akello H, Beyene T, van Lettow M. Public Health Action. 2013;(3)2:180-185(6). DOI: 10.5588/pha.13.0003 Read more

victoriaPublications Theme: HIV