Publications Theme: HIV


Survival functions for defining a clinical management Lost To Follow-Up (LTFU) cut-off in Antiretroviral Therapy (ART) program in Zomba, Malawi.

Rachlis B, Cole DC, van Lettow M, Escobar M. BMC Medical Informatics and Decision Making. 2016 May 5;16(1):52. DOI: 10.1186/s12911-016-0290-7 Read more

Breast enlargement in Malawian males on the standard first line antiretroviral therapy regimen: Case reports and review of the literature.

Kwekwesa A , Kandionamaso C, Winata N, Mwinjiwa E, Joshua M, Garone D, Bedell R,van Oosterhout JJ. Malawi Medical Journal. 2015 Sept;27(3): 115-117. DOI: 10.4314/mmj.v27i3.11 Read more

Neurocognitive Function at the First-Line Failure and on the Second-Line Antiretroviral Therapy in Africa: Analyses From the EARNEST Trial

Andrew Kambugu, Jennifer Thompson, James Hakim, Dinah Tumukunde, Joep J. van Oosterhout, Raymond Mwebaze, Anne Hoppe, James Abach, Charles Kwobah, Alejandro Arenas-Pinto, Sarah A. Walker, Nicholas I. Paton. Journal of Acquired Immune Deficiency Syndromes. 2016;71:506-513 DOI: 10.1097/QAI.0000000000000898 Read more

Population level usage of health services, and HIV testing and care, prior to decentralization of antiretroviral therapy in Agago District in rural Northern Uganda

G. Abongomera, S. Kiwuwa-Muyingo, P. Revill, L. Chiwaula, T. Mabugu, A. Phillips, E. Katabira, V. Musiime, C. Gilks, A. Chan, J. Hakim, R. Colebunders ,C. Kityo, D. M. Gibb, J. Seeley, D. Ford13 and for the Lablite Project Team. BMC Health Services Research. 2015;15:527. DOI: 10.1186/s12913-015-1194-4. Read more

CryptoDex: A randomised, double-blind, placebo-controlled phase III trial of adjunctive dexamethasone in HIV-infected adults with cryptococcal meningitis: study protocol for a randomised control trial.

Day J, Imran D, Ganiem AR, Tjahjani N, Wahyuningsih R, Adawiyah R, Dance D, Mayxay M, Newton P, Phetsouvanh R, Rattanavong S, Chan AK, Heyderman R, van Oosterhout JJ, Chierakul W, Day N, Kamali A, Kibengo F, Ruzagira E, Gray A, Lalloo DG, Beardsley J, Binh TQ, Chau TT, Chau NV, Cuc NT, Farrar J, Hien TT, Van Kinh N, Merson L, Phuong L, Tho LT, Thuy PT, Thwaites G, Wertheim H, Wolbers M. Trials. 2014 Nov;15:441. DOI: 10.1186/1745-6215-15-441. Read more

CYP2B6 c.983T>C polymorphism is associated with nevirapine hypersensitivity in Malawian and Ugandan HIV populations.

Carr DF, Chaponda M, Cornejo Castro EM, Jorgensen AL, Khoo S, Van Oosterhout JJ, Dandara C, Kampira E, Ssali F, Munderi P, Lalloo DG, Heyderman RS, Pirmohamed M. J Antimicrob Chemother. 2014 Nov;69(12):3329-34. DOI: 10.1093/jac/dku315. Read more

Hepatitis B virus (HBV) sub-genotype A1 infection is characterized by high replication levels and rapid emergence of drug resistance in HIV-positive adults receiving first-line antiretroviral therapy (ART) in Malawi.

Aoudjane S, Chaponda M, González Del Castillo AA, O’Connor J, Noguera M, Beloukas A, Hopkins M, Khoo S, van Oosterhout J, Geretti AM. Clin Infect Dis. 2014 Nov;59(11):1618-26. DOI: 10.1093/cid/ciu630. Read more

Effect of optional home initiation of HIV care following HIV self-testing on antiretroviral therapy initiation among adults in Malawi: a randomized clinical trial.

MacPherson P, Lalloo DG, Webb EL, Maheswaran H, Choko AT, Makombe SD, Butterworth AE, van Oosterhout JJ, Desmond N, Thindwa D, Squire SB, Hayes RJ, Corbett EL. JAMA. Aug 1, 2014;312(4):372-9. DOI: 10.1001/jama.2014.6493. Read more

The Lablite project: A cross-sectional mapping survey of decentralized HIV service provision in Malawi, Uganda and Zimbabwe.

Adrienne K Chan, Deborah Ford, Harriet Namata, Margaret Muzambi, Misheck J Nkhata, George Abongomera, Ivan Mambule, Annabelle South, Paul Revill, Caroline Grundy, Travor Mabugu, Levison Chiwaula, Fabian Cataldo, James Hakim, Janet Seeley, Cissy Kityo, Andrew Reid, Elly Katabira, Sumeet Sodhi, Charles F Gilks and Diana M Gibb. BMC Health Services Research. 2014 Aug 19;14:352. DOI: 10.1186/1472-6963-14-352 Read more

Peripheral Blood Mitochondrial DNA/Nuclear DNA (mtDNA/nDNA) Ratio as a Marker of Mitochondrial Toxicities of Stavudine Containing Antiretroviral Therapy in HIV-Infected Malawian Patients.

Kampira E, Dzobo K, Kumwenda J, van Oosterhout JJ, Parker MI, Dandara C. OMICS. 2014 Jul;18(7):438-45. DOI: 10.1089/omi.2014.0026. Read more

Follow-Up Visit Patterns in an Antiretroviral Therapy (ART) Programme in Zomba, Malawi.

Beth Rachlis, Donald C. Cole, Monique van Lettow, Michael Escobar, Adamson S. Muula, Farah Ahmad, James Orbinski, Adrienne K. Chan. PLoS ONE. 2014 July 17;9(7): e101875. DOI: 10.1371/journal.pone.0101875 Read more

Incomplete Recovery of Pneumococcal CD4 T Cell Immunity after Initiation of Antiretroviral Therapy in HIV-Infected Malawian Adults.

Sepako E, Glennie SJ, Jambo KC, Mzinza D, Iwajomo OH, Banda D, van Oosterhout JJ, A Williams N, Gordon SB, Heyderman RS. PLoS One. 2014 Jun 24; 24;9(6):e100640. Read more

HIV Associated Neurocognitive Disorders (HAND) in Malawian Adults and Effect on Adherence to Combination Anti-Retroviral Therapy: A Cross Sectional Study.

Christine M. Kelly, Joep J. van Oosterhout, Chisomo Ngwalo, Robert C. Stewart, Laura Benjamin, Kevin R. Robertson, Saye Khoo, Theresa J. Allain, Tom Solomon. PLoS ONE. 2014 Jun 10;9(6): e98962. DOI: 10.1371/journal.pone.0098962 Read more

Adolescent HIV disclosure in Zambia: barriers, facilitators and outcomes.

Gitau Mburu, Ian Hodgson, Sam Kalibala, Choolwe Haamujompa, Fabian Cataldo, Elizabeth D Lowenthal, David Ross. Journal of the International AIDS Society. 17 Mar 2014;17:18866. DOI: 10.7448/IAS.17.1.18866 Read more

A Reduction in Adult Blood Stream Infection and Case Fatality at a Large African Hospital following Antiretroviral Therapy Roll-Out.

Nicholas A. Feasey, Angela Houston, Mavuto Mukaka, Dan Komrower, Thandie Mwalukomo, Lyson Tenthani, Andreas Jahn, Mike Moore, Remco P. H. Peters, Melita A. Gordon, Dean B. Everett, Neil French, Joep J. van Oosterhout, Theresa J. Allain, Robert S. Heyderman. PLoS ONE. 2014 March 18;9(3):e92226. DOI: 10.1371/journal.pone.0092226 Read more

Assessment of second-line antiretroviral regimens for HIV Therapy in Africa.

N.I. Paton, C. Kityo, A. Hoppe, A. Reid, A. Kambugu, A. Lugemwa, J.J. van Oosterhout, M. Kiconco, A. Siika, R. Mwebaze, M. Abwola, G. Abongomera, A. Mweemba, H. Alima, D. Atwongyeire, R. Nyirenda, J. Boles, J. Thompson, D. Tumukunde, E. Chidziva, I.Mambule, J.R. Arribas, P.J. Easterbrook, J. Hakim, A.S. Walker, P. Mugyeni, EARNEST Trial Team. New England Journal of Medicine. 2014 Jul 17;371(3):234-47. DOI: 10.1056/NEJMoa1311274 Read more

Population Pharmacokinetic and Pharmacogenetic Analysis of Nevirapine in Hypersensitive and Tolerant HIV-Infected Patients from Malawi.

Dickinson L, Chaponda M, Carr DF, van Oosterhout JJ, Kumwenda J, Lalloo DG, Pirmohamed M, Heyderman RS, Khoo SH. Antimicrob Agents Chemother. 2014. DOI: 10.1128/AAC.02069-13. Read more

Mitochondrial subhaplogroups and differential risk of stavudine-induced lipodystrophy in Malawian HIV/AIDS patients.

Kampira E, Kumwenda J, van Oosterhout JJ, Dandara C. Pharmacogenomics. 2013;14(16):1999-2004. DOI: 10.2217/pgs.13.188 Read more

Women’s attitudes to HIV testing, disclosure and the involvement of male partners in a rural district of Malawi with high HIV prevalence.

Bedell RA, van Lettow M, Landes M. AIDS Care: Psychological and Socio-medical Aspects of AIDS/HIV. 04 Oct 2013;26(4):483-486. DOI: 10.1080/09540121.2013.841830 Read more

Longitudinal lactate levels from routine point-of-care monitoring in adult Malawian antiretroviral therapy patients: associations with stavudine toxicities.

Chagoma N, Mallewa J, Kaunda S, Njalale Y, Kampira E, Mukaka M, Heyderman RS, and Oosterhout JJ van. C Trans R Soc Trop Med Hyg. 2013;107:615–619. DOI: 10.1093/trstmh/trt074 Read more

Severe toxicity and polymerase-c gene abnormalities in Malawian adults on stavudine-based antiretroviral therapy.

van Oosterhout, Joep J.; Gardner, Kristiane; Mallewa, Janea; Kaunda, Symona; Kampira, Elizabethc; Payne, Brendane; Heyderman, Robert S.; Chinnery, Patrick. Pharmacogenetics and Genomics. 2013 Nov;23(11):624-626. DOI: 10.1097/FPC.0b013e3283655053 Read more

Updating a database of patient level ART data covering multiple and remote facilities in Zomba District, Malawi.

Argarwal M, Bourgeois J, Matengeni A, Bezanson K, van Schoor V, van Lettow M. Public Health Action. 2013 June 21:3(2):175-179(5). DOI: 10.5588/pha.12.0096 Read more

Using concept mapping to explore patient defaulting from an antiretroviral therapy program in the Zomba District of Malawi.

Rachlis B, Ahmad F, van Lettow M, Muula AS, Semba M, Cole DC. BMC Health Services Research. 2013;13:210. DOI: 10.1186/1472-6963-13-210 Read more

A taxonomy for community-based care programs focused on HIV/AIDS prevention, treatment, and care in resource-poor settings.

Rachlis B, Sodhi S, Burciul B, Orbinski J, Cheng A, Cole D. Global Health Action, North America. 16 Apr 2013. DOI: 10.3402/gha.v6i0.20548 Read more

Six-month mortality among HIV-infected adults presenting for antiretroviral therapy with unexplained weight loss, chronic fever or chronic diarrhea in Malawi.

van Lettow M , Åkesson A, Martiniuk ALC, Ramsay A, Chan AK, Anderson ST, Harries AD, Corbett E, Heyderman RS, Zachariah R, Bedell RA. PLoS ONE. 2012 Nov 19;7(11)e48856. DOI: 10.1371/journal.pone.0048856 Read more

Anti-retroviral treatment outcomes among older adults in Zomba District, Malawi.

Negin J, van Lettow M, Semba M, Martiniuk A, Chan AC, Cumming R. PLoS ONE. 2011;6(10). Read more

Outcome assessment of decentralization of ART provision in a rural district in Malawi using an integrated primary care model.

Chan AK, Mateyu G, Jahn A, Schouten E, Mlotha W, Kambanji M, and van Lettow M. Trop Med Int Health. 2010;15s1:90-97. Read more

Burden, Characteristics, Management and Outcomes of HIV-infected patients with Kaposi’s sarcoma in Zomba, Malawi.

Mwinjiwa E, Isaakidis P, Van Den Bergh R, Harries AD, Bezanson K, Thompson C, Joshua M, Akello H, Beyene T, van Lettow M. Public Health Action. 2013;(3)2:180-185(6). DOI: 10.5588/pha.13.0003 Read more

victoriaPublications Theme: HIV