The PURE Study

Improving Prevention of Mother-to-Child Transmission Treatment Uptake and Retention

research-context Context


Mother-to-child transmission of HIV is the most common source of HIV infection in children. In 2010, it was estimated that 20% of all children born in sub-Saharan Africa were exposed to HIV, resulting in 130,000 infections.

In 2011, Malawi introduced a public health approach to improve the effectiveness of its Prevention of Mother-to-Child Transmission (PMTCT) program by offering all HIV-infected pregnant and breastfeeding women lifelong antiretroviral therapy (ART) regardless of clinical stage or CD4 count. The strategy, called Option B+, has since been adopted by several other countries in the region and was included in the 2013 updated World Health Organization guidelines. Option B+ is expected to have benefits for HIV+ women, their HIV-exposed infants, and their HIV-uninfected partners. However, these benefits hinge on early initiation of PMTCT, good adherence, and long-term retention in care.

research-aim Aim


Through a three-arm cluster randomized control trial, the PURE study will evaluate whether the Option B+ standard of care with the addition of either clinic- or community-based peer support will improve the likelihood of mothers and families starting and remaining in PMTCT care.

 research-sitesSites


research-timeline Timeline


August 2012 – August 2017

research-partnerships Partnerships


Funders: World Health Organization, Foreign Affairs, Trade and Development Canada
Study Lead: Lighthouse Trust
Partners: Malawi Ministry of Health, Management Sciences for Health, University of North Carolina Project, University of Malawi – College of Medicine Malaria Alert Centre and University of Malawi – Chancellor College, London School of Hygiene and Tropical Medicine, mothers2mothers

research-team Study Team


Dr. Sam Phiri
Principal Investigator, Lighthouse Trust

Dr. Fabian Cataldo
Co-Investigator, Dignitas International

Dr. Monique van Lettow
Co-Investigator, Dignitas International

Dr. Megan Landes
Co-Investigator, Dignitas International

Florence Kasende
Study Coordinator, Dignitas International

research-info Contact


For more info, please email Dr. Fabian Cataldo at f.cataldo@dignitasinternational.org.


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